Introduction: An effective leadership is critical to the development of a safety culture within an organization. Patient safety in primary health care is an emerging field of research of increasing importance. Objective: This study has been conducted to explore the safety culture attitude toward patient safety to improve the quality and patient safety in primary health-care centers. Methods: A cross-sectional survey involving 288 medical staff in primary health-care centers in Al-Ahsa was conducted using an Arabic translated safety attitude questionnaire to assess the safety attitudes among health care center staff toward patient safety culture.